Borderline personality disorder is a common diagnosis among young women, especially as they adapt to their new roles as mothers. How does this affect their children, families, and communities at large? See highlights below or read the full article in Psychiatric Times here. 

motherhood and the 4 symptom domains of borderline personality disorder_elisabeth netherton_mindpath health

Women adapting to their new roles as mothers can struggle with substantial mental health challenges. Postpartum depression, for example, is widely understood as the most common condition faced by mothers after delivery. However, mothers can face many other overlooked psychiatric challenges across pregnancy, the postpartum period, and motherhood. Borderline personality disorder (BPD) is a common diagnosis among young women that is highly understudied in pregnancy and motherhood. 

Prevalence of BPD in the general population may be as high as 5.9%, around 10% in psychiatric outpatient clinics, and around 20% among psychiatric inpatients.1,2 BPD is overwhelmingly diagnosed in women; around 87% of those receiving diagnoses are female. It is also thought to be associated with a higher degree of disability in women.1 Average age upon diagnosis is 24.8 years. Delayed diagnosis is common, often happening after an average of 3.6 years of treatment.3 

“Motherhood” is a broad construct involving constant change: pregnancy, postpartum, infancy, toddlerhood, school-age children, teenager, empty-nesting. We can consider 4 main domains of symptoms within BPD: identity/sense of self, impulsivity, relationship difficulties, and affective instability. 

In the United States, the mean age of women at first birth is 26.9 years, which closely corresponds to the average age of women upon BPD diagnosis.4 By age 44 years, 85% of women in the United States have had at least 1 biological child, with an average of 2.1 children per woman.5 Based on these data, women with BPD are statistically likely to become mothers. 

Women with BPD have also been found to be at substantially higher risk of preterm delivery than women in a hospitalwide control group; their infants were more likely to have low Apgar scores.8 During the postpartum period, 23.1% of women seeking psychiatric inpatient admission to a mother-baby unit in Australia met criteria for BPD.8 Another 11.1% showed significant BPD features without meeting full diagnostic criteria.8 

Clinically, we see substantial symptom variability among women as they navigate motherhood, with some symptoms improving and others worsening. Although there is very little research addressing these symptom shifts directly, we can synthesize what we know from the literature and draw on clinical experience to examine how these symptoms are likely to change across the span of motherhood. 

Sense of Self

Personal identity is conceptualized through role commitments, a sense of inner agency, a world view that gives life meaning, and continuity across time. Motherhood has a profound impact on sense of self and can lead to a reevaluation of how autonomy, physical appearance, sexuality, and occupations influence these identities differently than they did prior to motherhood.11 

In women with BPD, there are often clinical improvements in patients’ sense of self and a reduction in their experience of internal emptiness in their new role as mother. However, this initial stabilization is often brief. As children begin the process of individuation, mothers with BPD may experience it as a threat to their own sense of self, with subsequent heightened distress and symptomatology.15 There is also an increase in distress for these mothers as their grown children leave home, with substantial challenges in reestablishing a sense of self independent of the role they played as a mother caring for children living at home. 


Impulsivity has a known negative impact on pregnancy. It is associated with a higher risk of unplanned pregnancy, risky sexual behaviors, and a risk for sexual victimization.16-18 

There is limited evidence that impulsivity increases during pregnancy and the postpartum period, although this notion is very understudied.19 Impulsivity in individuals with BPD commonly manifests in substance use disorders, with as many as 57% of individuals with BPD experiencing a comorbid substance use disorder.20 The negative impacts of substance use in pregnancy have been well documented. 

Impulsivity is also associated with safety concerns, such as self-injurious behavior and risk for suicide.21,22 Impulsivity is also associated with eating, particularly binge eating, which can impact the health of women and their babies during pregnancy as well as body image during the postpartum period. 

Relationship Difficulties

The development of healthy relationships requires “theory of mind,” or the ability to understand our own internal state and that of others. Theory of mind includes cognitive and affective components, to understand others’ thoughts/beliefs and emotional states.26,27 

Connected regions of the brain that are active when we exercise this ability are referred to as the “theory of mind network.”28 Mothers make use of this ability, as they coregulate affect, when their baby is distressed and they mirror the baby’s distress to facilitate soothing. 

During pregnancy, women experience changes in their brain architecture that likely strengthen their ability to care for and raise a child.29 These involve changes within the theory of mind network and have been shown to predict mother-baby attachment postpartum.30  

Relationships are particularly challenging for women with BPD. Adults with BPD have been shown to have significant deficits in theory of mind and often struggle to cooperate with others as a relationship progresses and to repair following a rupture in cooperation.34,35 

This makes women with BPD particularly vulnerable during the transition to motherhood and the postpartum period, when the ability to draw support from relationships is critical to maternal well-being. It also affects a mother’s ability to develop secure attachment with her baby, which is critical to child development. However, there is hope that the brain-based changes of motherhood might mitigate some of this risk or lend improvement in these areas. 

Affective Instability

Functional neuroimaging studies of patients with BPD have shown frontolimbic dysfunction that has a differential impact on negative emotionality and is consistent with clinical challenges around affective lability seen in adults with BPD.36 

Women with BPD struggle more with mood shifts in response to hormone fluctuations; that is, changes in ovarian hormone levels have been associated with fluctuations in negative emotionality and impulsivity in women with BPD. Fluctuations in hormone levels also characterize pregnancy and parturition, which may indicate that there is an increased risk in women with BPD for mood changes and symptom exacerbation during this period compared with women without BPD.37,38 

Concluding Thoughts

BPD traits vary individually over time and core traits of BPD can carry additional risk for distress as women transition to motherhood and parent young children. Additional research is needed to further understand the model of pathology for women with BPD as they enter motherhood and to determine strategies that can lead to resilience and health for mothers and their families. 

Dr Netherton is a psychiatrist and regional medical director with Mindpath Health. Dr Rohr is director of women’s mental health at Houston Methodist Hospital in Texas. 

Elisabeth Netherton, M.D.

Houston, TX

Dr. Elisabeth Netherton focuses on women’s mental health and personality disorders across the lifespan. Dr. Netherton understands the challenges women face and has experience in prescribing women during pregnancy and postpartum. She believes it is incredibly meaningful to see mothers feel better because this positively impacts them and their children. Dr. Netherton wants her patients to feel empowered and consider ... Read Full Bio »

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